At trezor.io/start, begin by connecting your Trezor device to your computer using the USB cable provided. Follow the prompts on the screen to start the setup process. You'll have options to create a new wallet or recover an existing one using your recovery seed. Safeguard your recovery seed in a secure location as it's essential for accessing your funds in case your device is lost or damaged. Confirm your settings and set up a PIN to complete the process securely. Trezor.io/start offers comprehensive instructions to ensure your Trezor device is configured safely and ready for use.